Polyendocrine metabolic ovarian syndrome (PMOS) is a hormonal and metabolic condition affecting women of reproductive age. It was known as polycystic ovary syndrome (PCOS) until May 2026, when an international consensus published in The Lancet adopted the new name to reflect the fact that the condition involves the endocrine, metabolic, reproductive, dermatological and psychological systems rather than the ovaries alone.
The condition occurs when the ovaries produce excess androgens, which may disrupt regular ovulation and cause a range of symptoms. Women with PMOS may have ovaries containing multiple small follicles visible on ultrasound, although many women with the condition do not, and pathological ovarian cysts are not a feature of PMOS.
PMOS can present differently in each individual. The condition may affect menstrual cycles, fertility, metabolism, and appearance. Common features include irregular or absent periods, difficulty conceiving, excessive hair growth (hirsutism), acne, weight gain, and insulin resistance. Early diagnosis and appropriate management can help address symptoms. They can help address symptoms and may support the prevention of long-term complications such as type 2 diabetes, cardiovascular disease, and endometrial cancer. Individual symptoms and progression may vary. Consultation with a healthcare professional is recommended for proper diagnosis and management.